Translation and Application of Gene Editing
December 2015The rapidly advancing developments in gene editing have numerous implications and applications for the cell and gene therapy field – from disease modelling through to the potential editing of patient-derived cells to modify/correct disorders.
The Gene Editing spotlight features a lead review from Prof. Andrew Bassett, Oxford University, UK discussing the main gene-editing technologies in detail: Zinc Fingers, TALENs and CRISPR-Cas9, comparing mechanisms of action, limitations and opportunities for future development and applications.
Building upon this, we present a series of Expert Insight articles discussing potential clinical applications in more detail including:
- Cystic fibrosis
- Duchenne Muscular Dystrophy
- Genetic blood disorders and hemoglobinopathies
Alongside the discussion of the incredible advances in gene editing applications, an ongoing patent dispute plays out in the media over the CRISPR-Cas9 technology. Dr Beatriz San Martin, Partner, FieldFisher, UK helps demystify and explain the IP situation and talks about the possible implications of the outcome of this dispute.
We also hear from gene editing industry leaders, Sangamo BioSciences, as Dr Fyodor Urnov discusses their exciting progress towards the clinic with zinc finger nucleases in our exclusive podcast interview.

Translation and Application of Gene Editing

Repurposing CRISPR-Cas systems as DNA-based smart antimicrobials

The scope and challenges of visualizing CRISPR-Cas9 gene editing in real time

Current gene editing strategies for the mucopolysaccharidoses

Recent advances in the use of ZFN-mediated gene editing for human gene therapy

In vivo genome editing as a therapeutic strategy for treatment of inherited retinal dystrophies: how close are we to realization?

Gene editing of peripheral blood T cells for cancer immunotherapy

Advances & challenges of using CRISPR-Cas9 gene editing for treating Duchenne muscular dystrophy

A Digital PCR-Based Method for Efficient & Highly Specific Screening of Genome Edited Cells

Dr Fyodor Urnov: The power and promise of ZFN-mediated genome editing

Spotlight on: Translation and application of gene editing

The promise of therapeutic genome engineering

Exciting developments in CRISPR/Cas9-mediated approaches for Duchenne MD

Beta testing: preclinical genome editing in β-globin disorders

Stem cell-derived organoid cultures and genome editing tools

Revolutionizing genome editing with CRISPR/Cas9: patent battles and human embryos

Fyodor Urnov: The power & promise of ZFN-mediated genome editing

Access the Gene Editing Resource Center

Learn how Droplet Digital PCR works

Free Webinar hosted by Bio-Rad

Simultaneous Quantification of HDR & NHEJ Alleles by Genome Editing Using ddPCR

Transfecting ZFNs, TALENs or CRISPR/Cas Using Nucleofector™ Technology

Genome Editing using Nucleofector™ Technology – Technical Reference Guide

Transfection of Genome Editing Tools Using Nucleofector™ Technology – Selected Publications
