Scaling up/out: cost-effective and robust transitioning through the clinic to commercial manufacture
Guest Editor:Jan Thirkettle, Chief Development Officer at Freeline Therapeutics Limited
Chief Development Officer at Freeline Therapeutics Limited
JAN THIRKETTLE is Chief Development Officer at Freeline, a Syncona-funded start-up focussed on liver-directed AAV gene therapy. Jan has extensive experience in the development and deployment of novel platforms including natural product and enzyme derived NCEs, biologics and gene therapies. Prior to joining Freeline Jan led the establishment of GSK’s Cell & Gene Therapy platform and was responsible for CMC/supply for Strimvelis, the first ex vivo gene therapy to receive an EU Marketing Authorisation Application. He has held industry positions spanning from discovery to commercial manufacturing, but is most passionate about late-state development, new technology introduction and project delivery. Jan holds an MA in Chemistry and a PhD in Biological Chemistry from Oxford University.