Optimal conditioning regimens for cord blood transplantation: advances and challenges

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Kristin Page & Mitchell Horwitz

Latest advances in cord blood applications & commercialization

Conditioning regimens of all intensities have proven effective for patients in need of umbilical cord blood transplantation. While total body irradiation (TBI) continues to play a prominent role in most adult and pediatric regimens, there are now highly effective regimens without TBI. Children with malignant and non-malignant disorders receive predominantly myeloablative conditioning regimens. The clinical need for less toxic regimens for adult patients, particularly those with co-morbidities, has prompted clinical research activity in reduced intensity and non-myeloablative regimens capable or facilitating engraftment of single or double umbilical cord blood grafts. Here, we will describe the evolution of many of these regimens and how they are currently being utilized in stem cell transplant centers throughout the world.

Submitted for review: Jun 29 2017 Published: Sep 6 2017
DOI: 10.18609/cgti.2017.057
Citation: Cell Gene Therapy Insights 2017;3(7), 559-571.
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