Kaylene M Young and Solène Ferreira
In 2015, 46.8 million people worldwide have been diagnosed with dementia. This figure is predicted to rise to 131.5 million people by 2050 . Alzheimer’s disease (AD) is the leading cause of dementia, and can be further divided into familial AD, which results from genetic mutation and has an early age of onset, and sporadic AD. Sporadic AD is by far the most prevalent form, and over the past decade numerous risk factors have been linked to its development. Aging is still the most significant risk factor, with more than 1 in 20 people over the age of 60 developing the disease. AD is characterized by the deposition of β-amyloid in the form of plaques, the aggregation of hyper-phosphorylated tau as intracellular neurofibrillary tangles, neuron loss, and brain atrophy. Many of the pathological features of AD were identified over a century ago, however new mechanisms driving the pathology are still being uncovered today .
Citation: Cell Gene Therapy Insights 2015; 1(2), 133-137.