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Cell & Gene Therapy Insights

Cell & Gene Therapy Insights

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Spotlight Article

A reproducible, high-throughput platform to quantitatively study AAVs

Viral vector bioprocessing & analytics: today’s key tools and innovation requirements to meet future demand

James White and Natalia Rodionova

The adeno-associated virus (AAV) has the potential for major therapeutic advances in the future due to its low immunogenic response in humans. Studying AAVs through sodium dodecyl sulfate-polyacrylamide gel (SDS-PAGE) electrophoresis presents multiple challenges in user variability and time consumption. In order to resolve these challenges, a microfluidic platform, the LabChip® GXII Touch system, was used to characterize AAV serotype 8 (AAV8) particles. This reproducible technology can be used for high-throughput, quantitative characterization of AAV particles.

DOI: 10.18609/cgti.2020.055
Citation: Cell & Gene Therapy Insights 2020; 6(3), 449–453
Open access
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