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Cell & Gene Therapy Insights

Cell & Gene Therapy Insights

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Responding to the challenges of flow cytometry in GMP product testing, a technical evaluation of the Accellix platform

Downstream Bioprocessing Update

Kevin W Johnson, Conor O’Malley, Steve Kunitake, Amanda Trent, Aaron Gassman, Jyostna Ivatury, Anna Brown and Geoff Hodge

Flow cytometry is a powerful tool used in the research and development of cell and gene therapy products. With this tool the researcher can gain valuable insight into the phenotype and function of populations of individual cells and how those cells respond to perturbations in their respective environments. In the development of cellular medicine, flow cytometry is used for assessment of culture health, phenotypic characterization of in process culture and final product, as well as functional characterization to quantify the effect of potential process changes as well as indicate the labs’ capability of making a safe and effective product on the lab bench.

DOI: 10.18609/cgti.2019.125
Submitted for review: August 17, 2019
Citation: Cell & Gene Therapy Insights 2019; 5(9), 1195-1205.
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