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Cell & Gene Therapy Insights

Cell & Gene Therapy Insights

Meeting the scalability challenge of downstream viral vector purification

Tuesday, November 12th @ 8:00 PST; 11:00 EST; 16:00 GMT; 17:00 CET

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In the expanding field of gene and cell therapy, continuous flow ultracentrifugation is slowly revealing its ability to overcome downstream bottlenecks. Unlike the more well-known tube rotor designs, continuous flow zonal UCF offers a unique ability to dynamically use revolving zones at high speeds to provide a scalable and cost-effective process for the purification and concentration of viral vectors.

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Seth Brittle, Process Engineer, Separation Technologies, Alfa Wassermann

As a Process Engineer at Alfa Wassermann Separation Technologies Seth develops customer methodologies, performs validation testing, and offers process support. He holds a doctoral degree in environmental science with an extensive background in chemistry, nanoscience, and biology. He has knowledge and experiences in many purification bioprocesses such as tangential filtration, chromatography, and centrifugation. He has previously worked for Louis Berger (now WSP) as a hydrogeochemist performing large-scale analytics on anthropogenic pollutants. Before that, he worked for the Air Force Institute of Technology as postdoctoral researcher developing radiation detection schemes to characterize and access high-performance polymeric nanocomposites.



Sandra Meriño, Global Project Director, Separation Technologies, Alfa Wassermann

Global Project Director Alfa Wassermann Separation Technologies group for 17 years managing process support, product installation and validation including PQ testing. Previously worked at Medeva (now Seqirus) in the UK as a downstream processing scientist working on traditional and recombinant viral and bacterial vaccine scale up and scale down. Holding a BSc Hons in Biological sciences and Biochemistry form Manchester University.

As Global Project Director, Sandra has managed process support, product installation and validation including product quality testing for Alfa Wassermann for more than 16 years. Previously she worked at Medeva (now Seqirus) in the UK as a downstream processing scientist working on traditional and recombinant viral and bacterial vaccine scale up and scale down. She has extensive knowledge and experience in ultracentrifugation operation as it applies to vaccine, viral vector, and cellular therapy research. She holds a Bachelor of Science degree with honors in Biological Sciences and Biochemistry from Manchester University.



Xiaotong Fu, PhD, Senior Engineer, Biogen

Dr.Xiaotong Fu is a senior engineer at Biogen, gene therapeutics downstream purification process development group. Xiaotong Fu is currently leading the downstream process development efforts to support multiple gene therapy programs at Biogen. Xiaotong Fu graduated from the Johns Hopkins University with a doctoral degree, focusing on micro-scale purifications using Lab-on-the-chip technology. He had multiple publications in both gene therapy and lab-on-the-chip fields. The most recent one was published on Human Gene Therapy Method (Aug2019)


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