Studying solid tumors and their micro-environment based on automated large-scale 3D fluorescence imaging

Profound analysis of the heterogeneous tumor physiology and cellular dynamics within the tumor microenvironment requires comprehensive 3D imaging data. Commonly used techniques of classic histology and 2D microscopy are unable to meet this need. In this webinar, we introduce the UltraMicroscope Blaze™, which enables high-resolution 3D visualization of large solid tumors and their microenvironment. This platform allows quantification of multiple tumor parameters and cell infiltration into the tumor (e.g. CAR T cell tracking) at subcellular resolution. The resultant 3D data from entire solid tumors support early drug development by providing new insights into drug delivery pathways, for example. Multiple smaller samples like spheroids can be imaged automatically in one run to reduce hands-on time. With cutting-edge light sheet optics the microscope operates as a virtual microtome which performs section-free high-resolution 3D imaging of large or multiple samples.

• Learn about large-scale 3D imaging with light sheet microscopy
• Gain insights into typical sample preparation protocols for light sheet microscopy
• Understand the benefits of light sheet microscopy in IO research
• Get an overview of how to image and analyze multiple organs or tumors
• Comprehend cellular tracking in solid tumors using light sheet microscopy

Nizar Yousif

Global Product Manager for Immuno-Oncology, Miltenyi Biotec

Dr. Nizar Yousif is the global Product Manager for Immunology and Immuno-Oncology at Miltenyi Biotec. He gained several years of experience in immunology research in academia and industry and has a profound knowledge in a wide range of immunology/neuroimmunology applications . Following his postdoctoral research at the Laboratory of Translational Psychiatry, University Medical Center, Freiburg, Germany, Nizar joined Miltenyi Biotec and is currently advancing the broad product portfolio for immuno-oncology applications.

Hussein Hamzeh

Global Microscopy Product Manager, Miltenyi Biotec

Dr. Hussein Hamzeh is the Microscopy Product Manager at Miltenyi Biotec, a position he has held since 2019. Prior to this, he worked as a post-doctoral scientist at the Max Planck Institute in Germany and MBL in Woods Hole, USA after completing his PhD at the former. This further stint in academia followed time as a research engineer in the development of multiphoton endoscopy at CNRS in France, his first job after obtaining his MSc. In Applied Physics from Lebanese University, Beirut.