Engineered immune cell therapy has revolutionised the field of cancer therapeutics. However, the success observed against haematological malignancies has not translated well to the more complex and refractory solid tumour environment.
This webinar will explore the reasons that underlie this and discuss the innovative strategies and gene editing technologies that are being employed to overcome these limitations. TALEN and CRISPR have already entered clinical trials and shown feasibility and safety in humans, paving the way towards the next generation of enhanced cell and gene therapies.
Fast-paced scientific advances and novel gene editing tools such as base editing and prime editing also look set to enter the ring and contribute towards efficient and safe manufacture of more effective and persistent engineered immune cell therapies against solid tumours. It is with much anticipation that clinicians and researchers closely monitor the rapid evolution of cell therapies and share their thoughts and insights on these exciting developments.