Mononuclear phagocytes in tissue: from inflammation to cancer
Sponsor
Live30 webinars are thirty-minute presentations designed to update you on the latest innovations, applications, and data in a fast yet interactive format.
Myeloid cells are an integral part of the innate immune system, and play a crucial role in orchestrating both innate and adaptive immune responses in the tissue microenvironment. Studies in experimental model systems have significantly increased our understanding of fundamental myeloid cell functions.
However, investigations in well-designed clinical cohorts using high-dimensional analytic pipelines including high-dimensional microscopy, are essential for comprehending the immune cell functions in human health and disease, such as inflammatory conditions and cancer.
This webinar will focus on spatial aspects of human mononuclear phagocytes (MNP), key players in neoplastic and inflammatory conditions. The work investigates MNP phenotype and functions, including their interactions with stromal cells, in clinical cohorts of patients with Langerhans cell histiocytosis, an inflammatory myeloid neoplasia, and in pediatric inflammatory bowel disease.
- Providing an overview of the mononuclear phagocyte system in humans
- Examining specific mononuclear phagocyte tissue identities during inflammation (pediatric inflammatory bowel disease) and neoplasia (Langerhans cell histiocytosis)
- Reviewing and discussing a basic analytic workflow for spatial protein data of stromal and immune cells
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