Live30 webinars are thirty-minute presentations designed to update you on the latest innovations, applications, and data in a fast yet interactive format.
Myeloid cells are an integral part of the innate immune system, and play a crucial role in orchestrating both innate and adaptive immune responses in the tissue microenvironment. Studies in experimental model systems have significantly increased our understanding of fundamental myeloid cell functions.
However, investigations in well-designed clinical cohorts using high-dimensional analytic pipelines including high-dimensional microscopy, are essential for comprehending the immune cell functions in human health and disease, such as inflammatory conditions and cancer.
This webinar will focus on spatial aspects of human mononuclear phagocytes (MNP), key players in neoplastic and inflammatory conditions. The work investigates MNP phenotype and functions, including their interactions with stromal cells, in clinical cohorts of patients with Langerhans cell histiocytosis, an inflammatory myeloid neoplasia, and in pediatric inflammatory bowel disease.
- Providing an overview of the mononuclear phagocyte system in humans
- Examining specific mononuclear phagocyte tissue identities during inflammation (pediatric inflammatory bowel disease) and neoplasia (Langerhans cell histiocytosis)
- Reviewing and discussing a basic analytic workflow for spatial protein data of stromal and immune cells
Egle Kvedaraite, MD, PhD
Physician for Clinical Pathology and Cancer Diagnostics & Neuropathology, Karolinska University Hospital
Egle Kvedaraite completed her MD in 2016 and her PhD in 2022 as part of the highly competitive Physician Scientist Training Program at Karolinska Institute in Sweden. She is currently a licensed physician and combines her clinical training in clinical pathology and cancer diagnostics, with a focus on neuropathology at Karolinska University Hospital, with research at the Department of Medical Biochemistry and Biophysics at Karolinska Institute. During her PhD, Dr. Kvedaraite focused on the study of human myeloid cells in cancer, inflammation, and infection, conducting research at the Center for Infectious Medicine (CIM) at Karolinska Institute. CIM was founded in 2002 as one of six national "Strategic Research Centers" in Sweden and has recently been ranked as the #1 center for translational medicine at Karolinska Institute. Additionally, Dr. Kvedaraite conducted research on myeloid cells at the Singapore Immunology Network, which is part of the Agency for Science and Technology and Research (ASTAR). Dr. Kvedaraite's research interests include human immunology, myeloid cells, and stromal-immune cell interactions in the tissue environment.