Precise mRNA purity assessment for accelerated therapeutic development and release testing

Variable pathlength technology is a UV-Vis-based spectroscopy technique that enables the measurement of multiple absorbance values through variable pathlengths, improving the accuracy and efficiency of nucleic acid analytics. Unlike traditional methods requiring fixed 1 cm cuvettes, variable pathlength technology systems like Ctech™ SoloVPE^® can adjust pathlengths from 5 µm to 15 mm, eliminating saturation and dilution errors. Additionally, SoloVPE automates data acquisition and analysis, significantly reducing processing time from hours to minutes while maintaining high reproducibility and compliance with regulatory standards. This article explores case studies showcasing variable pathlength technology’s effectiveness in measuring pDNA and mRNA purity, highlighting its role in streamlining processes and enhancing product development.

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