Opportunities and challenges in mRNA-LNP vaccine design

Vaccine Insights 2023; 2(3), 101–105

DOI: 10.18609/vac/2023.019

Published: 17 April 2023
Rein Verbeke, Pieter R Cullis

“Future research should focus on how much of the mRNA-LNP dose drains into lymph nodes and spreads systemically, which immune cell types are involved in the uptake, translation, and presentation of the mRNA-encoded antigens, and which cellular interactions potentially contribute to adverse events...”