Fine-tuning your mRNA-LNP formulation with an innovative cationic lipid library

Lipid nanoparticles (LNP) have demonstrated high efficiency delivering RNA therapeutics in vivo. However, the properties of such nanoparticles obtained with conventional ionizable lipids are often hard to modulate; particularly their biodistribution profile. As a result, ionizable LNPs often predominantly end up targeting the liver. One of the current challenges in the field consists of adjusting the particle chemical composition to the targeted application.

In this webinar, we discuss the characterization of a library of 10 innovative imidazolium-based cationic lipids as key components of cationic LNPs (cLNPs). We disclose their chemical structures and demonstrate their efficacy in generating LNPs through characterization of their hydrodynamic diameters, zeta potentials, encapsulation efficiencies, efficiency, and in vivo biodistribution.

Learn about a library of novel cationic lipids that can address current challenges for mRNA therapeutics, including:

• Modulating lipid nanoparticles (LNPs) properties
• Improving transfection efficiency of LNPs in vitro and in vivo
• Expanding the use of LNPs beyond the liver
• Enabling screening of the best suited lipid to adapt the biodistribution of LNPs according to therapeutic applications

Nathan Chaboche

Non-Viral Delivery Solutions Product Manager Associate at Polyplus Transfection

Nathan holds a master’s degree in Pharmaceutical Sciences, supplemented by a Master's degree in Management of Pharmaceutical Industries and Medical Technologies. He worked for 3 years at Servier in Business Development, in France and in the Netherlands. He started at Polyplus in 2021 as a Scientific Support Associate, and after 2 years, he changed roles internally in April 2023 to become Product Manager in charge of the Non-Viral Delivery solutions range.

Quentin Huaulmé

Research Scientist in R&D Chemistry at Polyplus Transfection

Quentin holds a PhD in organic chemistry from the University of Strasbourg. He developed his knowledge on polymer chemistry with two post-doctoral experiences at Merck (UK) and at CEA (France). After 2 years focusing on innovative polymers-based mRNA delivery systems at Polyplus, he is now in charge of the design of the new Polyplus’ in vivo products, and especially innovative cationic lipids as key LNP component.

Watch now

SPEAKERS

Nathan Chaboche

Non-Viral Delivery Solutions Product Manager Associate at Polyplus Transfection

Quentin Huaulmé

Research Scientist in R&D Chemistry at Polyplus Transfection

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