Lipid nanoparticles (LNP) have demonstrated high efficiency delivering RNA therapeutics in vivo. However, the properties of such nanoparticles obtained with conventional ionizable lipids are often hard to modulate; particularly their biodistribution profile. As a result, ionizable LNPs often predominantly end up targeting the liver. One of the current challenges in the field consists of adjusting the particle chemical composition to the targeted application.
In this webinar, we discuss the characterization of a library of 10 innovative imidazolium-based cationic lipids as key components of cationic LNPs (cLNPs). We disclose their chemical structures and demonstrate their efficacy in generating LNPs through characterization of their hydrodynamic diameters, zeta potentials, encapsulation efficiencies, efficiency, and in vivo biodistribution.
Learn about a library of novel cationic lipids that can address current challenges for mRNA therapeutics, including: