Hal E Broxmeyer
Latest Advances in Cord Blood Applications & Commercialization
Cord blood hematopoietic stem and progenitor cells have been used successfully for hematopoietic cell transplantation to treat a variety of malignant and non-malignant disorders. Use of cord blood has advantages and disadvantages as a source of transplantable cells compared to that of bone marrow and mobilized peripheral blood. Most recently, haplo-identical transplants have been competing with cord blood as a source of transplanted cells. Efforts are ongoing to modulate cord blood and recipients of cord blood transplantation for more efficacious transplant outcomes, in part in order to overcome the slower time to neutrophil, platelet and immune cell recovery of these compared to the other sources of transplantable cells. This review briefly describes the history of cord blood biology and hematopoietic cell transplantation, efforts to collect more stem cells and to expand and better allow them to home to the bone marrow for more efficient and rapid engraftment. A personal perspective for future efforts in these areas is also provided.
Submitted for review: Feb 20 2017 Published: Sep 6 2017
Citation: Cell Gene Therapy Insights 2017;3(7), 521-530.