Enhancing AAV process quality and efficiency: three case studies highlighting the benefits of upgraded analytics on downstream process development

E Hudspeth, I Green, T Dewosky et al

11 November 2024

Expert Insight

Upstream processing of viral vectors: a summary

Pardhasaradhi Mathi

29 July 2024

Expert Insight

Are we there yet? After 250+ AAV-based clinical trials, do we have a well-paved road toward first-in-human entry?

Long Chen, Chia Chu, Francesca Vitelli

10 May 2024

Expert Insight

Improving process efficiency to reduce cost-of-goods per dose in manufacturing of recombinant AAVs

G Thakur, S Mink, H Bak et al

03 May 2024

Expert Insight

Optimizing ddPCR assay for characterizing AAV vector genome integrity

Aishwarya Shevade, John S Reeves, Andrew D Tustian

03 August 2023

Expert Insight

Fine tuning AAV: machine learning the capsid

Joseph Rabinowitz, Ravi Kalia

08 July 2023

Expert Insight

The supporting role of plasmids in gene & cell therapy

Duarte Prazeres

06 July 2023

Expert Insight

A guided demonstration of the Counting Method Evaluation Tool (COMET) for implementing the ISO 20391-2 Cell Counting standard

L Pierce, D Newton, S P Lund et al

21 June 2023

Expert Insight

Exosomes: next generation vectors for drug delivery & gene therapy

Jess Morhayim, Jeroen de Vrij

12 December 2022

Expert Insight

Adeno-associated virus adsorption on different surfaces relevant to production of pre-clinical & clinical material

Amanda Zhang, Sara Cook, Ayda Mayer

01 October 2022

Expert Insight

Stabilizing DNA–PEI complexes improves scalability of suspension lentiviral viral vector and AAV processes

B Olden, H Seo, R Barnes et al

28 August 2022

Expert Insight

A new era of in vivo gene therapy: the applicability of a differentiated HSV-1 based vector platform for redosable medicines

Trevor Parry, Suma Krishnan, Domenick A Prosdocimo

26 June 2022

Expert Insight

Engineered exosomes: a transformative therapeutic modality

P Jones, D Carter, D Lowe et al

25 May 2022

Expert Insight

Adeno-associated virus process development: optimization & development of a scalable elution for polishing chromatography

Daniel Martin

11 April 2022

Expert Insight

Adeno-associated viral vector process development challenges in early research & preclinical study

Ashish Saksule

27 March 2022

Expert Insight

Commercial-scale lentiviral vector manufacturing: is the myth busted?

Hanna Leinonen

31 January 2022

Expert Insight

Next-generation DNA vectors: is the nS/MARt platform a viable alternative to viruses for autologous T-cell immunotherapy?

Matthias Bozza, Richard Harbottle

23 November 2021

Expert Insight

Analytical toolkit for rapid formulation development of rAAV gene therapies

Julie Yu Wei, Ying Cai, James Warren

22 October 2021

Expert Insight

Challenges in AAV manufacturing: the interplay of process variations, in-process characterization, and drug product quality

D Chu, H Acharya, E Springfield et al

21 October 2021

Expert Insight

The Chemistry Manufacturing and Controls (CMC) section of gene therapy-based INDs: overview in a changing landscape

Gabriela Denning, PhD

18 October 2021

Expert Insight

Scalable downstream process development for in vivo gene therapy products: understanding full/empty separation capabilities and challenges with ion exchange chromatography

Kumar Dhanasekharan

29 September 2021

Expert Insight