Salt-tolerant endonucleases, the benefits for viral vector manufacturing and a comparison of two marketed enzymes

Marc Struhalla, Svenja Michalek

26 March 2025

Innovator Insight

Achieving robust and scalable AAV empty/full capsid separation for gene therapy

Julio Huato, Mark Schofield

26 February 2025

Innovator Insight

Make more lentivirus and make it right the first time

Katherine Schewe

10 February 2025

Innovator Insight

Generation of novel AAV serotypes with enhanced infectivity, specificity, and lower toxicity via AAV capsid engineering platform

Y Bu, Y Pan, Y Zhong et al

03 December 2024

Innovator Insight

AAV downstream challenges: expert insights

N Clement, W Kish, N Laroudie et al

04 November 2024

Innovator Insight

Optimizing bioprocess purification: effective nucleic acid removal in high salt environments

Eleonora Turco, Joanna Niska-Blakie

30 October 2024

Innovator Insight

Control your AAV titers with in-line UV-Vis analysis and PAT-driven UF/DF systems

Brandon Goldberg

10 October 2024

Innovator Insight

How will process development and analytical innovation drive growth for the future of cell and gene therapies?

Mark Santos

07 October 2024

Innovator Insight

Precision in production: optimizing monitoring and quality control for high-value plasmids

Oleksandr Karpenko

02 October 2024

Innovator Insight

Mastering AAV production: best practices for small to large-scale manufacturing success and reduced development times

Emily Jackson-Holmes

01 October 2024

Innovator Insight

AAV process intensification using high-salt lysis and salt-tolerant endonuclease

A Lass-Napiorkowska, C Toenjes, M P Zoeller et al

16 September 2024

Innovator Insight

It’s a match: cell line engineering for AAV manufacturing expands the options for therapeutic programs

Dovile Woods

27 August 2024

Innovator Insight

Quantitative analysis of lipids and nucleic acids in lipid nanoparticles using monolithic column

N Pavlin, M Bavčar, T Kovačič et al

29 July 2024

Innovator Insight

Overcoming challenges in gene therapy analytics

Anthony J Blaszczyk, Ana Carreras González

25 July 2024

Innovator Insight

Advancing AAV production with high-throughput screening and transcriptomics

Christopher A Reid, Markus Hörer, Mohammad A Mandegar

23 July 2024

Innovator Insight

Alternative solutions to separate AAV full and empty capsids using anion exchange

Åsa Hagner-McWhirter, Mark Schofield

24 June 2024

Innovator Insight

Increasing efficiency in AAV-based gene therapy production: platform optimization with multiserotype AAV affinity capture

Nicolas Laroudie, Tiago Albano

20 June 2024

Innovator Insight

Commercial-scale manufacture of lentivirus for ex vivo and in vivo therapies

Rachel Legmann, Michelle Yen Tran

04 June 2024

Innovator Insight

Accelerating AAV process development with a PAT-driven TFF system

Teva Smith

21 May 2024

Innovator Insight

AAV capsids separation is critical for advancing gene therapies

Timotej Žvanut, Andreja Gramc Livk, Aleš Štrancar

20 May 2024

Innovator Insight

Evaluation and performance of an AAV affinity resin: a CDMO case study

Spyros Gerontas, Buzz Lobbezoo

03 May 2024

Innovator Insight