BioInsights - Vol 7 Issue 6

CELL & GENE THERAPY INSIGHTS

Vol 7 Issue 6

Cell & Gene Therapy Vol 7 Issue 6

Download PDF

Featuring

Issue Spotlight: Gene delivery platform evolution
Focus: Vector characterization & analytics
Other articles
Webinars

Gene delivery platform evolution

Editorial

Expanding gene therapy and gene editing strategies to large and complex indications

Expanding gene therapy and gene editing strategies to large and complex indications

Carmen Unzu, Florie Borel

Innovator Insight

Scalable upstream process development for the suspension-based production of lentiviral vectors for CAR T cell therapies with multiparallel & benchtop bioreactor systems & DoE methodology

Scalable upstream process development for the suspension-based production of lentiviral vectors for CAR T cell therapies with multiparallel & benchtop bioreactor systems & DoE methodology

D Riethmüller, D Nyamay’antu, D Bollmann

Interview

Next steps in AAV preclinical and translational R&D

Next steps in AAV preclinical and translational R&D

Anna Tretiakova PhD, Shari Gordon

Coming of age: taking the next steps with non-viral gene delivery

Coming of age: taking the next steps with non-viral gene delivery

Matt Stanton

Progressing genetic medicines at the interface of gene therapy and gene editing

Progressing genetic medicines at the interface of gene therapy and gene editing

Dr Albert Seymour

FastFacts

Cell and gene manufacturing: a case study approach to overcoming challenges – expert perspectives and solutions

Cell and gene manufacturing: a case study approach to overcoming challenges – expert perspectives and solutions

Steven Thompson

Plasmid processing for mRNA, gene therapy and other vector applications

Plasmid processing for mRNA, gene therapy and other vector applications

Henrik Ihre

Viewpoint

The dose makes the poison: next generation AAV vectors can save the day

The dose makes the poison: next generation AAV vectors can save the day

Julia Fakhiri, Jihad El Andari

A bright future for lipid nanoparticles in gene therapy

A bright future for lipid nanoparticles in gene therapy

Hongwei Zhang

Next-generation viral vector platforms for gene therapy, vaccine, and oncolytic virotherapy applications

Next-generation viral vector platforms for gene therapy, vaccine, and oncolytic virotherapy applications

Inanç Ortaç

Vector characterization & analytics

Interview

The A to Z of QbD

The A to Z of QbD

Michael Lehmicke

Innovator Insight

Addressing the challenges of purification and quality control in gene therapy

Addressing the challenges of purification and quality control in gene therapy

A Bhattacharya, A Chang, L Kopp et al.

COVID-19 mRNA vaccine approvals: key lessons for cell & gene therapy and mRNA therapeutic development

COVID-19 mRNA vaccine approvals: key lessons for cell & gene therapy and mRNA therapeutic development

J Barberio, C Kröner, V Indurthi et al.

FastFacts

Slope spectroscopy for gene therapy applications

Slope spectroscopy for gene therapy applications

Development & validation of a robust commercial solution for measuring residual kanamycin-resistant plasmid DNA

Development & validation of a robust commercial solution for measuring residual kanamycin-resistant plasmid DNA

Tania Chakrabarty

Viewpoint

Recent evolution in Process Analytical Technology for viral vectors

Recent evolution in Process Analytical Technology for viral vectors

Tony Bou Kheir

Journal articles

Innovator Insight

Lentiviral vectors: key challenges and new developments

Lentiviral vectors: key challenges and new developments

Natalia Elizalde, PhD, Juan Carlos Ramírez, PhD

Interview

Regulatory CMC in cell and gene therapy: navigating an evolving space

Regulatory CMC in cell and gene therapy: navigating an evolving space

Lawrence C. Starke

FastFacts

Dedicated regulatory support packages for TheraPEAK® GMP Solutions

Dedicated regulatory support packages for TheraPEAK® GMP Solutions

Hippolitus Odukwu

Mycoplasma detection in cell therapy products: GMP-compliant implementation & validation of a commercial real-time PCR assay for routine quality control & lot release

Mycoplasma detection in cell therapy products: GMP-compliant implementation & validation of a commercial real-time PCR assay for routine quality control & lot release

Valentina Becherucci

Strategies to advance the donor selection process for cell therapies to improve outcomes

Strategies to advance the donor selection process for cell therapies to improve outcomes

M Maiers, P Wang Petersdorf, K Wadsworth et al.

Addressing the challenges of purification & quality control in gene therapy

Addressing the challenges of purification & quality control in gene therapy

D Bhattacharya, L Kopp, K PhD et al.