Vol 10 Issue 5

CELL AND GENE THERAPY INSIGHTS

June 2024 Issue

Vol 10 Issue 5

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Featuring

Issue Spotlight: Viral and non-viral vector platform evolution
Upstream processing 2024
Other articles
Webinars

SPOTLIGHT

Viral and non-viral vector platform evolution
Zhenghong Gao
Guest Editor:
Zhenghong Gao, Director, Non-Viral Delivery at AskBio

Foreword

Viral and non-viral vector platform evolution

Viral and non-viral vector platform evolution

Zhenghong Gao
18 June
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Review

Switching from ex vivo to in vivo: approaches and considerations for generating cell therapies directly in the patient upon in vivo gene delivery

Switching from ex vivo to in vivo: approaches and considerations for generating cell therapies directly in the patient upon in vivo gene delivery

Semih U Tareen
2 June
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Self-replicating RNA for mRNA vaccine development

Self-replicating RNA for mRNA vaccine development

Kenneth Lundstrom
2 June
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Innovator Insight

It’s a match: cell line engineering for AAV manufacturing expands the options for therapeutic programs

It’s a match: cell line engineering for AAV manufacturing expands the options for therapeutic programs

Dovile Woods
26 August
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Commentary

What are the issues associated with developing gene therapies for rare disease and are the current development models working?

What are the issues associated with developing gene therapies for rare disease and are the current development models working?

Samir Nuseibeh, Els Henckaerts
19 June
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FastFacts

Get your non-viral T cell engineering process ready for clinical manufacturing

Get your non-viral T cell engineering process ready for clinical manufacturing

Melanie Rietenbach
4 June
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Viewpoint

Expanding the therapeutic index of lipid nanoparticles: potential key for clinical translation success

Expanding the therapeutic index of lipid nanoparticles: potential key for clinical translation success

Zhenghong Gao
11 June
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Interview

Developing focused ultrasound as a novel gene delivery tool to overcome the blood–brain barrier

Developing focused ultrasound as a novel gene delivery tool to overcome the blood–brain barrier

Rikke Hahn Kofoed
28 May
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Advancing capsid engineering: improving tropism and delivery efficiency of AAV

Advancing capsid engineering: improving tropism and delivery efficiency of AAV

Li Ou
26 March
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Vectors FOCUS

Upstream processing 2024

Expert Insight

Upstream processing of viral vectors: a summary

Upstream processing of viral vectors: a summary

Pardhasaradhi Mathi
28 July
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Interview

Revolutionizing AAV manufacturing: innovations in process and capsid development

Revolutionizing AAV manufacturing: innovations in process and capsid development

Michael DiBiasio-White
2 June
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Journal articles

Innovator Insight

Alternative solutions to separate AAV full and empty capsids using anion exchange

Alternative solutions to separate AAV full and empty capsids using anion exchange

Åsa Hagner-McWhirter, Mark Schofield
23 June
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Increasing efficiency in AAV-based gene therapy production: platform optimization with multiserotype AAV affinity capture

Increasing efficiency in AAV-based gene therapy production: platform optimization with multiserotype AAV affinity capture

Nicolas Laroudie, Tiago Albano
19 June
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Analytical strategies for sterility and mycoplasma testing in biotherapies: from early development to production scale-up

Analytical strategies for sterility and mycoplasma testing in biotherapies: from early development to production scale-up

Sharon Rouw, Michael Brewer
16 June
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Commercial-scale manufacture of lentivirus for ex vivo and in vivo therapies

Commercial-scale manufacture of lentivirus for ex vivo and in vivo therapies

Rachel Legmann, Michelle Yen Tran
3 June
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Can primary packaging selection help mitigate particulate risks in cell and gene therapy manufacturing?

Can primary packaging selection help mitigate particulate risks in cell and gene therapy manufacturing?

Sean Werner, Joshua Jendusa, Stuart Curbishley
3 June
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Commentary

Navigating the EU joint clinical assessment process: key considerations for manufacturers of ATMPs and oncology medicines

Navigating the EU joint clinical assessment process: key considerations for manufacturers of ATMPs and oncology medicines

Clare L Hague
17 June
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Infographic

mRNA purification: 5 key pieces of expert advice

mRNA purification: 5 key pieces of expert advice

26 June
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Conference Insight

2023 NIFDS-PMDA-USP Workshop for Advanced Therapies, day 1

2023 NIFDS-PMDA-USP Workshop for Advanced Therapies, day 1

M Kim, B Clarke, C G Chase et al.
3 June
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Webinars