Vol 10 Issue 9

CELL AND GENE THERAPY INSIGHTS

October 2024 Issue

Vol 10 Issue 9

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Featuring

Issue Spotlight: Gene editing
Downstream processing 2024
Other articles
Webinars

SPOTLIGHT

Gene editing
Houria Bachtarzi
Guest Editor:
Houria Bachtarzi, Principal Consultant at BIOCELLGENE Consulting Ltd

Expert Insight

Therapeutic epigenome editing: safety and quality considerations of a new class of gene-targeted medicines

Therapeutic epigenome editing: safety and quality considerations of a new class of gene-targeted medicines

Houria Bachtarzi, Tim Farries
14 October
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Review

Coming of age: an overview of the growing toolbox for gene editing and its use in CGT applications

Coming of age: an overview of the growing toolbox for gene editing and its use in CGT applications

C Fuentes, J Staudhammer, M Pope et al.
6 October
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Viewpoint

Gene delivery: persistent challenges call for a reference measure

Gene delivery: persistent challenges call for a reference measure

Max Ryadnov
21 October
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Pioneering the future of non-viral genome engineering

Pioneering the future of non-viral genome engineering

Hao Wu
17 September
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Interview

Advancing gene therapies for β-hemoglobinopathies with novel genome and epigenome editing tools

Advancing gene therapies for β-hemoglobinopathies with novel genome and epigenome editing tools

Annarita Miccio
17 September
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Beyond CRISPR: exploring the next frontier in gene editing technologies

Beyond CRISPR: exploring the next frontier in gene editing technologies

Devyn Smith
17 September
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Vectors FOCUS

Downstream processing 2024

Research Article

Displacement chromatography for enrichment of rAAV genome-containing capsids using weak organic acid

Displacement chromatography for enrichment of rAAV genome-containing capsids using weak organic acid

T Zekovic, P Greback-Clarke, E Vorst et al.
23 October
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Innovator Insight

AAV process intensification using high-salt lysis and salt-tolerant endonuclease

AAV process intensification using high-salt lysis and salt-tolerant endonuclease

A Lass-Napiorkowska, C Toenjes, M P Zoeller et al.
15 September
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Interview

Process optimization for AAV-based gene therapy: insights on downstream purification

Process optimization for AAV-based gene therapy: insights on downstream purification

Srivatsan Ramesh
16 October
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Journal articles

Expert Insight

Challenges encountered when delivering advanced therapy investigational medicinal products in the National Health Service in the UK: a pharmacy perspective

Challenges encountered when delivering advanced therapy investigational medicinal products in the National Health Service in the UK: a pharmacy perspective

B Amirloo, B Duran, I Sanna et al.
29 October
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Innovator Insight

Optimizing bioprocess purification: effective nucleic acid removal in high salt environments

Optimizing bioprocess purification: effective nucleic acid removal in high salt environments

Eleonora Turco, Joanna Niska-Blakie
30 October
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Extracellular vesicles: setting your path to IND with advanced characterization packages

Extracellular vesicles: setting your path to IND with advanced characterization packages

Davide Zocco
28 October
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Control your AAV titers with in-line UV-Vis analysis and PAT-driven UF/DF systems

Control your AAV titers with in-line UV-Vis analysis and PAT-driven UF/DF systems

Brandon Goldberg
9 October
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Supporting efficacy and scaling with a next-generation T cell AOF formulation medium

Supporting efficacy and scaling with a next-generation T cell AOF formulation medium

Alan Gutowski, Joanna Kern
30 September
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FastFacts

High-throughput process development and scale-up to 2,000 L for rAAV production to address unmet patient needs

High-throughput process development and scale-up to 2,000 L for rAAV production to address unmet patient needs

Pouria Motevalian
14 October
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Bag-to-bag consistency: homogeneous cell count distribution in biopharmaceutical aliquotation

Bag-to-bag consistency: homogeneous cell count distribution in biopharmaceutical aliquotation

Alexander Fuchs
6 October
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Webinar Digest

Commercial-scale manufacture of lentivirus for ex vivo and in vivo therapies

Commercial-scale manufacture of lentivirus for ex vivo and in vivo therapies

Rachel Legmann, Michelle Yen Tran
8 October
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Poster

Trends in innovation for enhanced gene therapy downstream process intensification and product yield

Trends in innovation for enhanced gene therapy downstream process intensification and product yield

Rachel Legmann
28 October
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Webinars