Improving the enrichment of mononuclear cells for CAR T cell therapies: the importance of platelet depletion
Cell & Gene Therapy Insights 2021; 7(10), 1275;
10.18609/cgti.2021.170
Published: 17 November 2021
FastFacts
Watch the video or read the poster to learn:
- Why optimal mononuclear cell enrichment is critical to the successful start of a standard autologous CAR-T manufacturing process
- How a platelet removal step upstream rather than downstream of density gradient separation can reduce the amount of red blood cell contamination
- Working with a closed and automated system for both platelet removal and density gradient separation minimizes the risk of contamination, operator variability, and errors, while also reducing procedure time