DNA Vectors – a Key Enabler of Tomorrow’s Cancer Immunotherapies

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Richard Paul Harbottle

Richard Paul Harbottle is currently the Principle Investigator and Group Leader of the DNA Vector Research Group at the German Cancer Research Centre (DKFZ) in Heidelberg. Their research focuses on the development of DNA vector technologies for gene therapy with particular focus on the application of minimally sized scaffold/matrix attachment region (S/MAR) vectors. They have recently made a breakthrough in their DNA vector design that allows the application of our vector in stem cells and in primary human cells. For the first time they have generated a DNA vector system that can provide persistent transgene expression in primary human T cells without the risk of integration-mediated genotoxicity and they are currently developing a range of novel DNA vectors for anti-tumor immunotherapy. This DNA vector can also be used to genetically modify stem cells and they have recently shown for the first time that they can generate stable mouse embryonic cell lines and can generate transgenic mice from these modified cells.

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