Logistics by design: a framework for advanced therapy developers to create optimal Logistics Platforms

Published: 2 January 2019
Expert Insight
Simon Ellison,
Simon Ellison
Senior Manager, Advanced Therapies
Simon is the Senior Manager, Advanced Therapies at Fisher BioServices. With the aim of building a supply chain solution that addresses the industries challenge of operations at commercial scale. Whilst at the Cell and Gene Therapy Catapult Simon identified the need for, and built the Seamless Freight portfolio. He also helped develop the commercial operating model for the Catapult Manufacturing Centre that resulted in the first collaborators entering, and the start of a cluster forming around this unique facility.Prior to this Simon was the Head of Commercial at NHS Blood and Transplant (NHSBT) where he merged the needs of the industry with NHSBTs manufacturing capability. This enabled multiple UK and International organisations to move their therapies forwards.
Ryan McCoy,
Ryan McCoy
Lead Technical Scientist at Cell and Gene Therapy Catapult
Mark Bell,
Mark Bell
Manufacturing Development Scientist at Cell and Gene Therapy Catapult
Kelly Frend
Kelly Frend

Advanced therapeutic medicinal products (ATMPs) are delivering a new wave of treatment options for unmet healthcare needs. Their impact however, will be severely truncated if supply chain infrastructure is unable to robustly and cost-effectively connect patient to product. Guaranteeing logistical success is becoming an ever-increasing focal point as the field rapidly delivers. Establishing a seamless development approach, including logistics, will be critical in delivering a successful commercial logistics strategy. Paramount to facilitating ATMP commercial realisation is a support structure for logistics planning. In this article we present ‘Logistics by Design’ (LbD) – a framework for logistics-based decision making, based in-part, on Quality by Design principles. This is accompanied by case studies that illustrate the value in applying LbD principles early in the development lifecycle, thereby de-risking the probability of logistics strategy failure.

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