POROSTM CaptureSelectTM AAVX elution optimization study for optimized recovery of AAV6 capsids

Cell & Gene Therapy Insights 2022; 8(7), 809;

DOI: 10.18609/cgti.2022.124

Published: 27 August 2022
FastFacts
Jenny England


Watch the video or view the poster to learn about:

  • Optimum elution conditions to maximize recovery of AAV6 capsids
  • The impact of pH (2.0, 2.5, and 3.0) and excipient effect (arginine, MgCl2, and propylene glycol) on AAV recovery
  • High-throughput screening and RoboColumn approaches

Dr Jenny England is an R&D Manager in the Application group in Purification and Pharma Analytics at Thermo Fisher Scientific. Jenny is a biophysicist by training and earned her PhD from Georgetown University. After graduate school, she did a post doc at the National Cancer Institute that focused on structure-based drug design for protein kinase complexes. Jenny currently leads the application group for process development of the POROS resin products for antibody, mRNA, plasmid, and viral vector purification. Additionally, Jenny evaluates new and emerging technologies that can be applied to solve unmet customer needs in the bioproduction workflow.