Lentiviral titer determination: rapid & robust molecular methods suitable for validation

High-quality recombinant lentiviral vectors (LVV) are key for transgene delivery in many cell and gene therapies, including several of the FDA-approved CAR T-cell products. Critical to the success of these biologics are reliable methods to characterize and quantitate LVV. This poster highlights the challenges of current LV vector quantitation methods and describes two qPCR assays that enable quantitation and correlation of total and infectious lentivirus particles designed to facilitate LVV analytics in process development and manufacturing QC.

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