Future-proof your AAV process with a complete producer cell line

Cell & Gene Therapy Insights 2023; 9(7), 851–858

10.18609/cgti.2023.106

Published: 10 August 2023
Innovator Insight
Dovile Gruzdyte

Stable producer cell lines helped to make mAb therapies the powerhouses they are today. To deliver on the promise of AAV-based gene therapy, we need similar technology. The challenge is that multiple genetic elements—rep, helper, capsid, and gene of interest— must be present. Ideally, everything needed to produce the required rAAV would be stably integrated into a single cell line. This article will describe an all-inclusive cell line platform that can be customized for a specific gene of interest and capsid.