The range of technology options for nucleic acid delivery and genome engineering continues to expand, with a number of promising platforms now entering the clinic. David McCall, Senior Editor, Cell & Gene Therapy Insights, speaks with Zoltán Ivics, Head of Research Centre, Division of Hematology, Gene and Cell Therapy at the Paul-Ehrlich-Institut, about recent progress and next steps for one such example—the Sleeping Beauty transposon system.