Strategies to accelerate AAV chromatography process development

Following rapid growth in the gene therapy sector, the viral vector manufacturing industry is currently facing the key challenge of enabling and optimizing large-scale AAV production. Cleanable, reusable affinity resins can help to reduce costs in downstream purification of AAV vectors. This article provides a technical overview of rapid process development for an AAV capture step, using AVIPure® AAV affinity resins in two case studies. A high-throughput design of experiments framework will be shared on how to effectively identify desirable conditions for AAV chromatography. 

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