An automated 24-hour CAR-T manufacturing process
Cell & Gene Therapy Insights 2024; 10(4), 441–452
DOI: 10.18609/cgti.2024.058
Published: 8 May
Innovator Insight
As the cell therapy field progresses, manufacturing challenges like patient safety, cost, automation, closed operation, and scalability must be addressed with improved capabilities and workflows. Leveraging new cell therapy technologies and tools to develop innovative end-to-end workflows can enable more cost-effective cell therapy processes and workflows. This article presents an automated and shortened lentiviral-based CAR-T workflow using the GibcoTM CTSTM Detachable DynabeadsTM CD3/CD28 magnetic beads, GibcoTM CTSTM Detachable DynabeadsTM Release Buffer, and GibcoTM CTSTM DynaCellectTM Magnetic Separation System.