Accelerating AAV process development with a PAT-driven TFF system

Ultrafiltration/diafiltration represents a crucial step in bioprocessing, but traditional methods can pose a range of challenges. Some of these issue stem from current mass-dependent methods used in tangential flow filtration (TFF) systems. This article describes streamlined process development with a system uniquely controlled by real-time titer measurement acquired through in-line variable pathlength spectroscopy. AAV case study data from real users demonstrate automated process control, exhibiting the system’s efficacy across various final endpoints.

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