Intensified production of recombinant vesicular stomatitis virus-based vectors by tangential flow depth filtration

Watch the video or view the poster to learn more about: How viral vector production using a TFDF perfusion system can result in a 460% increase in space-time yield How using a TFDF system can allow continuous virus harvesting and clarification in one step The great potential of the TFDF perfusion system towards the establishment of intensified vector production

Béla Brühlmann brings over a decade of expertise in biotechnology to his role as a Field Application Scientist for Upstream Bioprocessing, supporting biopharma customers across Central Europe with scientific and technical guidance and specializing in XCell® ATF and KrosFlo TFDF® technologies. Prior to joining Repligen, Béla previously worked as the Bioprocess Application Specialist for Infors HT, Project Engineer at IE Life Science Engineering and Scientist at the Institute of Bioprocess Technology (Zurich University of Applied Sciences, ZHAW) and Institute of Molecular Systems Biology (Swiss Federal Institute of Technology, ETH). Béla earned a BSc in Biotechnology and a MSc in Pharmaceutical Biotechnology.

Sven is an early-stage career scientist, with a master’s degree in Technical Biology, currently working at the Max Planck Institute in Magdeburg, Germany, in the Department of Bioprocess Engineering, as a PhD student. With expertise in up- and downstream processing, process automation, and different cultivation systems, he combines comprehensive knowledge and practical skills to optimize bioprocessing workflows and enhance production efficiency. His main focus is on process characterization, optimization, and intensification of processes to produce viral vectors, vaccines, and oncolytic viruses in bioreactors, in cooperation with several industrial partners. He is co-/author of seven peer-reviewed publications.

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