Supporting efficacy and scaling with a next-generation T cell AOF formulation medium

Cell & Gene Therapy Insights 2024; 10(9), 1203–1219

DOI: 10.18609/cgti.2024.138

Published: 1 October
Innovator Insight
Alan Gutowski, Joanna Kern

Cell culture media are critical to successful cell therapy production, serving as a source of essential nutrients and maintaining the physiological conditions necessary for optimal cell growth and function. The use of well-defined, animal origin-free (AOF) media is increasingly recognized as being pivotal in ensuring experimental reproducibility, minimizing contamination risks, and addressing stringent regulatory requirements. This article explores the CTS™ OpTmizer™ One serum-free medium, an innovative AOF formulation tailored for T cell expansion. This medium is designed to enhance the early memory T cell phenotype, improve cell viability, and facilitate scalability, positioning it as a crucial tool for both preclinical research and clinical manufacturing.