Control your AAV titers with in-line UV-Vis analysis and PAT-driven UF/DF systems

Ultrafiltration/diafiltration (UF/DF) is a critical step in bioprocessing, especially in gene therapy. However, traditional methods often face significant challenges due to process variability and a heavy reliance on off-line titer analysis. This dependency can lead to delays and inconsistencies, hindering the ability to achieve precise and reproducible results. This article explores a novel tangential flow filtration system that leverages real-time, in-line titer measurement through in-line variable pathlength spectroscopy to control the UF/DF process.

Please enter your email to access content Read now