Optimizing bioprocess purification: effective nucleic acid removal in high salt environments

Cell & Gene Therapy Insights 2024; 10(9), 1291–1302

DOI: 10.18609/cgti.2024.147

Published: 30 October
Innovator Insight
Eleonora Turco, Joanna Niska-Blakie

Efficient cell lysis and host cell DNA removal are crucial in biopharmaceutical purification, especially for viral vectors. This article will discuss how an advanced salt-active endonuclease can enhance bioprocess purification workflows by effectively removing nucleic acid impurities and meeting stringent regulatory standards.