Demystifying AAV affinity capture: mapping AAV affinity ligand footprints with cryo-electron microscopy

Cryo-electron microscopy (cryo-EM) provides high-resolution structures of AAV capsids and binding partners. Structures of several AAV-affinity ligands with the target capsids elucidate the mechanism of affinity resin capture. This poster delves into how these ligands engage the AAV capsids, and how these results can accelerate process development for these important gene therapy vectors.

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