Personalization in advanced cellular ImmunoTherapeutics: activities in Ireland

Advanced cellular immune therapeutics have transformative potential for an expanding range of diseases, including cancer, autoimmunity, and various immune-related conditions. Despite these advances, significant barriers need to be addressed to achieve improved efficacy, access, safety, and robust manufacturing. In this insight article, we present research activities in Ireland that focus on a) understanding and directing cellular heterogeneity for improved cellular therapeutics through control of metabolism during the biomanufacturing process and b) designing, biomanufacturing, and translating personalized advanced cellular immune therapeutics by creating an All-Ireland Research Center that leverages academic, manufacturing, regulatory, and clinical expertise to deliver a sustainable all-island ecosystem of innovation in cellular therapeutics.

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