CAR-T manufacturing intensification: the next wave of CAR-T commercialization

Cell & Gene Therapy Insights 2025; 11(2), 295–306

DOI: 10.18609/cgti.2025.034

Published: 3 April
Innovator Insight
Alexey Bersenev, Emilie Kleiren, John Knighton, Paul Bowles

Since the commercialization of the first CAR-T therapies, these revolutionary treatments have reshaped the landscape of cancer therapy, offering unprecedented hope to patients with hematologic malignancies. Here, a panel of industry and healthcare sector experts to discuss the critical intersection of commercialization strategies and manufacturing technology in advancing the next wave of CAR-T therapies to market. They explore the current industry status and the latest innovations that have the potential to optimize manufacturing processes for scale-up or scale-out, impacting cost of goods (CoGs) and manufacturing success to meet the growing demand and ensure broader patient access.