Scale-up and scale-out - what do we really need and how will we get there?

CELL AND GENE THERAPY INSIGHTS

September 2021

Scale-up and scale-out - what do we really need and how will we get there?

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Foreword

Scale-up and scale-out: what do we really need and how will we get there?

Scale-up and scale-out: what do we really need and how will we get there?

15 October 2021

Editorial

Improving the yield of rAAV manufacturing with HeLa producer cells lines to ensure patient access

Improving the yield of rAAV manufacturing with HeLa producer cells lines to ensure patient access

Expert Insight

Scalable downstream process development for in vivo gene therapy products: understanding full/empty separation capabilities and challenges with ion exchange chromatography

Scalable downstream process development for in vivo gene therapy products: understanding full/empty separation capabilities and challenges with ion exchange chromatography

Kumar Dhanasekharan

29 September 2021

Innovator Insight

cGMP manufacturing made easy: a case study by ElevateBio

cGMP manufacturing made easy: a case study by ElevateBio

Michael Paglia, Shannon Eaker

24 November 2021

Scaling-up the production of stem cell-derived extracellular vesicles in stirred-tank bioreactors

Scaling-up the production of stem cell-derived extracellular vesicles in stirred-tank bioreactors

Aurélie Tacheny

29 September 2021

Applying a closed, modular, semi-automated system to CAR T cell therapy manufacturing

Applying a closed, modular, semi-automated system to CAR T cell therapy manufacturing

14 September 2021

Expert Roundtable Video

Expert Roundtable: Evolution in AAV process development: 2022 and beyond

Expert Roundtable: Evolution in AAV process development: 2022 and beyond

Alejandro Becerra, Matthias Hebben, Michael Mercaldi

11 October 2021

Expert Roundtable: overcoming challenges in analytical assays for cellular therapies

Expert Roundtable: overcoming challenges in analytical assays for cellular therapies

Jara Joedicke, Marsilius Mues

11 October 2021

Expert Roundtable

Expert Roundtable: overcoming challenges in analytical assays for cellular therapies

Expert Roundtable: overcoming challenges in analytical assays for cellular therapies

Jara Joedicke, Marsilius Mues

13 October 2021

Expert Roundtable: evolution in AAV process development: 2022 and beyond

Expert Roundtable: evolution in AAV process development: 2022 and beyond

12 October 2021

FastFacts

Cell and gene manufacturing: a case study approach to overcoming challenges – understanding the value of an expert supplier

Cell and gene manufacturing: a case study approach to overcoming challenges – understanding the value of an expert supplier

Sean Werner, Adam Shields

Getting closer to the in vivo environment with human AB serum

Getting closer to the in vivo environment with human AB serum

Viewpoint

From start-up to scale-up: a journey through AAV process development

From start-up to scale-up: a journey through AAV process development

Kevin Mouillesseaux

Viral vector gene delivery: balancing safety, efficacy and dose

Viral vector gene delivery: balancing safety, efficacy and dose

Thijs Gerritzen

Interview

Reaping the benefits in scalability: the flexibility of an in-house gene therapy manufacturing strategy

Reaping the benefits in scalability: the flexibility of an in-house gene therapy manufacturing strategy

Alexandria Forbes, PhD

15 October 2021

Scaling up viral vector production: the importance of quality

Scaling up viral vector production: the importance of quality

Jeffrey Lacouchie

Industrializing viral vector manufacture

Industrializing viral vector manufacture

Daniel Teasley, Katherine Schewe

15 September 2021

Webinars

Scalable, flexible manufacture: simplifying cell & gene therapy production

Scalable, flexible manufacture: simplifying cell & gene therapy production

J Bornholdt AIA PE LEED AP, N Kulkarni PhD, C Houts

8 September 2021

AAV manufacturing with stable producer cells for industrial scale vector production

AAV manufacturing with stable producer cells for industrial scale vector production

Ben Hudjetz

16 September 2021

Get your non-viral T cell engineering process ready for clinical manufacturing

Get your non-viral T cell engineering process ready for clinical manufacturing

M Rietenbach, S Wild, K Patel

21 September 2021

GMP manufacturing for exosome-based therapies: the critical role of analytics and process design for clinical production and scale-up

GMP manufacturing for exosome-based therapies: the critical role of analytics and process design for clinical production and scale-up

Marcos Langtry, Davide Zocco

28 September 2021

cGMP manufacturing made easy – a case study by ElevateBio

cGMP manufacturing made easy – a case study by ElevateBio

Michael Paglia, Shannon Eaker

14 October 2021