AAV manufacturing with stable producer cells for industrial scale vector production
Sep
16
2021
On demand

AAV manufacturing with stable producer cells for industrial scale vector production

Thursday 08:00 PDT / 11:00 EDT / 16:00 BST / 17:00 CEST
Sponsor
AAV manufacturing with stable producer cells for industrial scale vector production

As gene therapy moves towards more frequent indications with large patient cohorts or systemic administration, incomparably higher amounts of vector material are required. Stable helper virus-free AAV producer cell lines are the technology of choice to elevate the manufacturing scale of AAV gene therapy vectors to this next level. 

The stable ELEVECTA® producer platform offers an “easy-to-scale” production platform in which AAV production is simply started via induction as all components necessary for AAV production are stably integrated in the cells. The platform makes AAV production as simple as monoclonal antibody production.

  • Eliminate any transient transfection/helper virus infection step from your AAV production process
  • Achieve reliable AAV production by simple induction of suspension producer cells
  • Easy scale-up of AAV production instirred tank bioreactors
  • Increase AAV production in stirred tank bioreactor up to E15 vg/L using an intensified process
  • Free choice of stable producer cell line based on HEK 293 or CAP® cells.
Ben Hudjetz
Ben Hudjetz
Senior Scientist, Cell Line Development, CEVEC, now part of Cytiva

Ben Hudjetz is a Senior Scientist in the Cell Line Development Department at CEVEC. He holds a PhD in Cell Biology and Virology from the Heinrich-Pette-Institute (University of Hamburg). Before joining CEVEC in 2017 he worked on the development of nucleic acid-based drugs. In his current position his main scientific focus is the development and optimization of CEVEC’s ELEVECTA stable AAV producer cell lines based on HEK293 cells.

SPEAKERS

Ben Hudjetz
Ben Hudjetz
Senior Scientist, Cell Line Development, CEVEC, now part of Cytiva

You might also like

Same-section spatial multiomics: a platform for detailed analysis of the solid tumor TME

Same-section spatial multiomics: a platform for detailed analysis of the solid tumor TME

Emily Neil, Ariadna Pascual
27 June
in 65
Days
Register
Advancing cell therapy: innovations in polymer-based encapsulation and delivery

Advancing cell therapy: innovations in polymer-based encapsulation and delivery

J Katz, M Delic-Schlumbohm, B Yevgeniy et al.
5 June
in 43
Days
Register
Pure and simple: understanding LNP analytics for better mRNA-based drugs

Pure and simple: understanding LNP analytics for better mRNA-based drugs

Adam Crowe
29 May
in 36
Days
Register
Empowering patient care: in-process and quality control solutions for cellular therapies

Empowering patient care: in-process and quality control solutions for cellular therapies

Christin Tischner, Simon Lennartz
23 May
in 30
Days
Register
T cells from beginning to end: optimizing leukopak and drug product cryopreservation

T cells from beginning to end: optimizing leukopak and drug product cryopreservation

Meredith Safford, ShaNelle Yelity
22 May
in 29
Days
Register