BioInsights - Round table discussion: Successful suspension-based viral vector manufacturing scale-up, from process development to clinics
Sep
7
2022
On demand

Round table discussion: Successful suspension-based viral vector manufacturing scale-up, from process development to clinics

Sponsor
Round table discussion: Successful suspension-based viral vector manufacturing scale-up, from process development to clinics

Live30 webinars are thirty minute presentations designed to update you on the latest innovations, applications and data in a fast yet interactive format.

As gene therapies move toward commercialization, the journey to manufacture a high-quality product while achieving economies of scale and reducing facility footprint can be challenging. Join us for this panel webinar discussion and meet gene therapy thought leaders and experts from industry and academia, including Dr. Timothy Cripe (Nationwide Children’s Hospital), Lenore Giannunzio (Andelyn Biosciences), Dr. Cassie-Marie Peigné (Polyplus) and Dr. Denis Kole (Pall Corporation) as they discuss best practices to successful suspension-based viral vector manufacturing scale-up.

Attendees will learn:

  • How to plan for long-term success and achieve versatility and flexibility using scalable manufacturing technologies and platforms. 
  • How to reach critical milestones smoother and faster with partners including end-to-end technology solution suppliers and contract and development manufacturing organizations (CDMOs). 
  • Expert opinions on opportunities and future perspectives in gene therapy.

Denis Kole, PhD

Director, Accelerator SM Process Development Services,Pall Corporation, USA 

Denis received his undergraduate degree in Biology from Clark University and his PhD from Worcester Polytechnic Institute in Massachusetts, where he studied stem cell biology and cellular reprogramming. Denis spent two years as a post-doctoral researcher studying cellular microenvironments and 3D tissue engineering of skeletal muscle tissue models. Prior to joining Pall, Denis spent 9 years in the biotech field holding several positions at large pharma and Contract Research Organizations (CROs), supporting upstream and downstream processes for early discovery programs. He joined Pall in 2017 and currently leads the Process Development Services (PDS) team in Westborough MA. Prior to leading the PDS team Denis led the US technical field applications team supporting the adaptation of continuous bioprocessing and bioprocess intensification solutions.

Lenore Giannunzio, BS

Principal Research Scientist. Andelyn Biosciences, USA

Lenore Giannunzio is a Principal Research Scientist at Andelyn Biosciences working in the MS&T department. She is currently working on scale-up of Andelyn’s bioreactor production and purification platform. Previously, she worked at Nationwide Children’s Hospital in the GMP Production Facility as the Process Development Manager for AAV and Operations Manager for Cell Based Therapies. At NCH, she developed and implemented production and purification processes that are now being used at Andelyn. Lenore has also worked in contract manufacturing and analytical testing at Battelle; in fermentation and dry chemistry testing at GDS Technology (now EKF/StanBio), and in protein purification at Michigan State University and Alma College. Lenore has a BS in biochemistry from Alma College in Alma, Michigan.

Cassie-Marie Peigné, PhD

Bioprocess Applications Specialist Team Leader, Polyplus, USA

Cassie-Marie Peigné, PhD. is the Bioprocess Applications Specialist Team Leader at Polyplus®, a leading provider of upstream process solutions for advanced biologic and Cell and Gene Therapy production from research to commercial grade. Cassie completed her PhD in Immunology at the University of Nantes, followed by a postdoctoral position in Infectious Diseases at the Okinawa Institute of Science and Technology, before joining Polyplus® in 2018.

Timothy Cripe, M.D., PhD

Principal Investigator, Nationwide Children’s Hospital, USA

Timothy P. Cripe, MD, PhD is chief of the Division of Hematology and Oncology at Nationwide Children’s Hospital, a Gordon Teter Endowed Chair in Pediatric Cancer at Nationwide Children’s Hospital and a Professor of Pediatrics at The Ohio State University. Dr. Cripe received his undergraduate degree in Biochemistry from Princeton University and his M.D. and Ph.D. in Genetics from the University of Iowa. He completed his pediatric residency training at the University of Iowa Children’s Hospital and his subspecialty fellowship training in pediatric hematology/oncology from Dana-Farber Cancer Institute/Children’s Hospital, Boston and the University of Colorado/Children’s Hospital, Denver. He was on faculty at the University of Wisconsin-Madison and Cincinnati Children’s Hospital prior to coming to Nationwide Children’s. He has been a principal investigator of a research laboratory studying virotherapy and gene therapy for cancer for the past 27 years, funded by numerous NIH R25, R01, P01, P50 and U54 grants and non-profit foundations. Most recently, he is a co-founder of Vironexis Biotherapeutics, Inc., developing adeno-associated virus gene therapy for cancer.

SPEAKERS

Denis Kole
Denis Kole
Director of Accelerator℠ Process Development Services, Pall Corporation, USA
Lenore Giannunzio
Lenore Giannunzio
Principal Research Scientist, Andelyn Biosciences, USA
Cassie-Marie Peigné
Cassie-Marie Peigné
Bioprocess Applications Specialist Team Leader, Polyplus, USA
Timothy Cripe
Timothy Cripe
Principal Investigator, Nationwide Children’s Hospital, USA

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