Development of anti-AAV assay for detection of pre-existing AAV immunity

Zhe Liu received her PhD in neurobiology from King’s College London in 2002. She joined Labcorp Early Development at the Huntingdon site as a Staff Scientist in April 2020. Zhe is a subject matter expert for immunoassay and performs development and validation work.

She has extensive laboratory experience in cell-based assay, immunoassay and flow cytometry in both academia and industry. In particular, she has been working in the CRO sector for 15 years with substantial experience in assay development, validation and sample analysis of ADA, PK, Biomarker and Potency.

John Chappell has approximately 25 years of experience in the Contract Research industry supporting both preclinical and clinical drug development. He has specialized in supporting biological compounds from an analytical perspective e.g. Pharmacokinetic, Immunogenicity and Biomarker analysis. He is particularly interested in validation requirements and ensuring that data generated will be acceptable to the regulatory authorities.

He has spoken at many international conferences on various topics including Oligonucleotide analysis, Biomarker Analysis, Immunogenicity and the analytical support of Biosimilar programs.

He now leads the Application Support and Service teams for Gyros Protein Technologies.