NK cells are effector lymphocytes of the innate immune system that control several types of tumors and microbial infections by limiting their spread and subsequent tissue damage. Genetically engineered primary human NK cells for clinical immuno-oncology applications hold great promise due to their potent antitumor properties and demonstrated safety in an allogeneic setting.
One of the key challenges faced by the cell therapy industry is the expansion and editing of NK cells using conventional methods. In this presentation, we will discuss how various cell therapy products developed by Thermo Fisher Scientific, including the Cell Therapy Systems™ (CTS) Xenon™ Electroporation System and CTS TrueCut™ Cas9 Protein, enable the generation, expansion, and processing of large numbers of functionally viable human CAR NK cells.
We will present data demonstrating successful engineering of CAR NK cells at clinical scale as measured by knock-out efficiency, anti-Meso3 knock-in, post-editing phenotype, viability, expansion over 3 weeks, and functionality shown by cytotoxicity in a cancer cell model.
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