We know viral titer determination is essential for the safe and effective dosing of gene therapy products, but methods used to measure viral titer continue to improve and evolve. In this webinar, John Bechill (Principal Scientist, Analytics, Modalis Therapeutics), Peng Wang (Senior Scientist, Viral Vector Analytical Team Lead, Lonza) and Mark White (Associate Director of Biopharma and Translational Product Marketing, Bio-Rad), will discuss the need for accurate viral titer determination, traditional approaches to measuring viral titer, and the field’s trajectory into the future.
Recent advances in technology for viral titer measurement improve the accuracy and precision of these assays, overcoming persistent challenges and meeting the demands of the growing gene therapy landscape. These technological developments in determining viral purity and identity are key steps in fully realizing the potential of AAV- and lentiviral-mediated gene therapies.
Attend this webinar to discover:
- The why and how to measure viral titer
- An overview of the traditional methods used to determine a viral titer
- Recent advances in measuring viral titer
- Future directions and path to realizing the potential of accurate and precise viral titer determination
John Bechill
Principal Scientist, Analytics at Modalis Therapeutics
John Bechill, PhD is a Principal Scientist at Modalis Therapeutics within the Bioprocess group. In the Bioprocess group, he leads the analytical group which supports upstream and downstream AAV production. The analytics team focuses on methods of AAV characterization including AAV tittering, residual impurity measurements, and potency assay development. He received his PhD in Molecular Biology from Loyola University, and his career has focused on the development of analytical assays to characterize viral propagation.
Peng Wang
Senior Scientist, Viral Vector Analytical Team Lead at Lonza
Peng Wang earned his doctorate in Chemical and Biomolecular Engineering from UCLA in 2013. After his postdoctoral training at Harvard University in the Department of Chemistry and Chemical Biology, he worked as Senior Research Scientist at MD Anderson Cancer Center. In his current role as Senior Scientist at Lonza Research and Development Team, he is leading an analytics team to develop platform assays for AAV, Lenti and, Exosome products.
Mark White
Associate Director, Biopharma Applications at Bio-Rad Laboratories
Mark White has played a key role in the development of multiple core technology capabilities and assays alongside a multidisciplinary team of biologists and engineers at Bio-Rad and previously at Berkeley Lights Inc. Mark obtained his PhD in Biomedical Sciences at the University of California, San Francisco.