T cells from beginning to end: optimizing leukopak and drug product cryopreservation
May
22
2024
On demand

T cells from beginning to end: optimizing leukopak and drug product cryopreservation

Wednesday 08:00 PDT / 11:00 EDT / 16:00 BST / 17:00 CEST
Sponsor
T cells from beginning to end: optimizing leukopak and drug product cryopreservation

T cell therapies, such as CAR-T therapies, are rapidly emerging as a powerful new treatment and potential cure for cancer. Understanding the optimal conditions to cryopreserve T cells is an important step towards developing better processes and better T cell therapies.

In this webinar, we will help you learn better strategies for cryopreserving leukapheresis material for T cell processing, and how to extend leukopak stability for added flexibility in manufacturing T cell therapies.

We will also present data on finding the right balance between excipients and cryoprotectants during drug product formulation, while exploring how formulation can affect the phenotype and function of the T cell product.

  • Why cryopreservation of drug substance and drug product is important for successful CAR-T therapies
  • Better strategies for cryopreserving leukapheresis material for T cell processing
  • How to extend leukopak stability for processing in T cell therapies
  • Striking the right balance in drug product formulation for excipients and cryoprotectants
  • How formulating the drug product can affect cell phenotype and function
Meredith Safford
Meredith Safford
Process Development Scientist at Charles River Laboratories

Meredith is a process development scientist at Charles River Lab's Hanover, MD site, a CDMO that focuses on cell and gene therapies. Her projects have included hematopoietic and mesenchymal stem cells, cancer cell lines, and primary immune cells.

Meredith has a PhD in Biology from Johns Hopkins University and an MS in Healthcare Management from Johns Hopkins Carey Business School. Her post-doctoral fellowship research projects at Johns Hopkins School of Medicine and at the National Institute on Aging focused on T cell activation and anergy induction. Before joining Johns Hopkins' Advanced Academic Programs as a Biotechnology faculty member, Meredith gained scientific publication experience working on the editorial staff of the Journal of Immunology.

ShaNelle Yelity
ShaNelle Yelity
Process Development Associate III at Charles River Laboratories

ShaNelle Yelity is a Process Development Associate III at Charles River Laboratories. She obtained her BS in Chemistry from Austin Peay State University in Clarksville, TN. Upon graduation, she went to work in a food science lab, where she developed many of her scientific skills. After several years, she decided to pursue a Master of Education and successfully became a Level 5 educator of all science curricula and a school counselor within the Memphis City Schools system. Her desire to return to the industry was ignited when she was given an opportunity to join Cognate BioServices 5 years ago in the QC/Bioassasy department. She transferred to Process Development in Hanover, MD 4 years ago to further enhance her skills. Her mantra and daily motto is, “Smile, you truly never know how your smile can brighten somebody’s day.”