Control your AAV titers with in-line UV-Vis analysis and PAT-Driven UF/DF systems

Ultrafiltration/Diafiltration (UF/DF) is a critical step in bioprocessing, especially in gene therapy. However, traditional methods often face significant challenges due to process variability and a heavy reliance on off-line titer analysis. This dependency can lead to delays and inconsistencies, hindering the ability to achieve precise and reproducible results.

Learn how PAT-driven tangential flow filtration (TFF) systems can leverage real-time, in-line titer measurement to control the UF/DF process, enabling precise and consistent monitoring of AAV titer concentrations. By harnessing real-time data on capsid titer, genome titer, and empty/full ratio, the accurate attainment of targeted titer results can be ensured.

Attend this webinar to find out about:

• Enabling real-time monitoring and precise control of titer concentration throughout the UF/DF process
• Accelerating lab-scale testing with reduced manual intervention, enhancing process efficiency and speed
• Comparative performance evaluation of novel versus conventional UF/DF methods

Brandon Goldberg

Senior Analytical Application Specialist at Repligen

Brandon Goldberg is a Senior Bioanalytical Application Specialist at Repligen, where he has dedicated 7 years to advancing bioanalytical technologies and ensuring that customers can effectively implement and utilize advanced bioprocessing technologies, specializing in Process Analytical Technology (PAT) solutions.

In his role, Brandon combines technical support, training, implementation and validation assistance, and ongoing collaboration to help customers achieve their bioprocessing goals efficiently and effectively. He focuses on helping customers implement and validate both at-line and in-line analytical solutions, driving process optimization with the FlowVPX and SoloVPE Systems.

A graduate of Central Connecticut State University in May 2016, Brandon has been active in the pharmaceutical industry ever since. He remains committed to his professional network in Connecticut, regularly connecting with colleagues and old friends to share insights and foster collaborations.

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SPEAKERS

Brandon Goldberg

Senior Analytical Application Specialist at Repligen

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