Control your AAV titers with in-line UV-Vis analysis and PAT-Driven UF/DF systems
Jul
11
2024
Upcoming webinar

Control your AAV titers with in-line UV-Vis analysis and PAT-Driven UF/DF systems

Thursday 08:00 PDT / 11:00 EDT / 16:00 BST / 17:00 CEST
Sponsor
Control your AAV titers with in-line UV-Vis analysis and PAT-Driven UF/DF systems

Ultrafiltration/Diafiltration (UF/DF) is a critical step in bioprocessing, especially in gene therapy. However, traditional methods often face significant challenges due to process variability and a heavy reliance on off-line titer analysis. This dependency can lead to delays and inconsistencies, hindering the ability to achieve precise and reproducible results.

Learn how the new PAT-driven tangential flow filtration (TFF) system leverages real-time, in-line titer measurement through in-line variable pathlength spectroscopy to control the UF/DF process. This innovative approach enables precise and consistent monitoring of AAV titer concentrations during UF/DF processes. The system provides real-time data on capsid titer, genome titer, and empty/full ratio, ensuring the accurate attainment of targeted titer results.

This webinar will demonstrate the automated process control capabilities of the KrosFlo® KR2i RPM AAV System, showcasing its effectiveness across various final endpoints. Join us to explore how this technology provides unparalleled advantages for scalability and efficiency in bioprocessing.

  • Utilization of In-line Variable Pathlength Technology (VPT) for real-time monitoring and precise control of titer concentration throughout the UF/DF process
  • Implementation of an automated TFF system to accelerate lab-scale testing with reduced manual intervention, enhancing process efficiency and speed
  • Comparative evaluation of the KR2i RPM System performance versus conventional UF/DF methods
Brandon Goldberg
Brandon Goldberg
Senior Analytical Application Specialist at Repligen

Brandon Goldberg is a Senior Bioanalytical Application Specialist at Repligen, where he has dedicated 7 years to advancing bioanalytical technologies and ensuring that customers can effectively implement and utilize advanced bioprocessing technologies, specializing in Process Analytical Technology (PAT) solutions.

In his role, Brandon combines technical support, training, implementation and validation assistance, and ongoing collaboration to help customers achieve their bioprocessing goals efficiently and effectively. He focuses on helping customers implement and validate both at-line and in-line analytical solutions, driving process optimization with the FlowVPX and SoloVPE Systems.

A graduate of Central Connecticut State University in May 2016, Brandon has been active in the pharmaceutical industry ever since. He remains committed to his professional network in Connecticut, regularly connecting with colleagues and old friends to share insights and foster collaborations.