Industry highlights: switching from manual to automated hematopoietic stem cell (HSC) gene engineering
Nov
6
2024
On demand

Industry highlights: switching from manual to automated hematopoietic stem cell (HSC) gene engineering

Wednesday 08:00 PST / 11:00 EST / 16:00 GMT / 17:00 CET
Sponsor
Industry highlights: switching from manual to automated hematopoietic stem cell (HSC) gene engineering

Live30 webinars are thirty-minute presentations designed to update you on the latest innovations, applications, and data in a fast yet interactive format.

Genetic modification of CD34+ cells offers a promising approach for treating inherited disorders such as sickle cell disease, ß-thalassemia, and primary immunodeficiencies. Current manufacturing processes are often manual, involving significant handling and user interaction, which increases the risk of human error. Looking ahead to clinical trials and therapeutic applications, transitioning to an automated manufacturing process early can minimize user intervention and reduce clean room requirements. This shift leads to more reproducible and standardized manufacturing processes, ultimately resulting in safer cell products.

In this webinar, Ana Rubio from Orchard Therapeutics will provide valuable insights into transitioning from manual to automated hematopoietic stem cell gene engineering using the CliniMACS Prodigy® HSC Engineering process. She will also present data from a case study highlighting the benefits of this transition.

Attend this webinar to:

  • Learn about the CliniMACS Prodigy® HSC Engineering process, which automates viral transduction of HSCs
  • Discover how to transition from manual to automated HSC gene engineering
  • Understand common challenges in automation and how to overcome them
Andreia  Marques Gomes
Andreia Marques Gomes
Global Product Manager for Clinical Hematopoietic Stem Cell Portfolio at Miltenyi Biotec

Andreia conducted her PhD projects at the Icahn School of Medicine at Mount Sinai in New York where she has uncovered new mechanisms underlying hematopoietic reprogramming and definitive hematopoiesis specification. Andreia joined Miltenyi Biotec in 2023 and currently, as Global Product Manager for Hematopoietic Stem Cells Engineering, she works with her colleagues to develop automated, closed and scalable manufacturing solutions for hematopoietic stem cells in the CliniMACS Prodigy Platform.

Ana Rubio Gomes
Ana Rubio Gomes
Scientist II, Technical Development at Orchard Therapeutics

Ana is a passionate scientist with experience in gene and cell therapies, stem cell biology, immunology, and tissue regeneration. She has worked in various acclaimed academic institutions and biotechnology companies, including The Scripps Research Institute and Autolus Ltd.

She holds a BSc in Biotechnology from Universidad Europea de Madrid, an MSc in Genes, Drugs, and Stem Cells – Novel Therapies from Imperial College London, and a Postgraduate Diploma in Biotechnology Management from the University of California, Riverside.

Since 2021, Ana has worked at Orchard Therapeutics where she focuses on the design and implementation of HSC-based gene-modified cell manufacturing processes.

Ute Bissels
Ute Bissels
Group Leader for Hematopoietic Stem Cells at Miltenyi Biotec
Ute earned a Biotechnology degree from the University of Münster and a PhD from RWTH Aachen University, specializing in molecular biology and hematopoietic stem cells. Since joining Miltenyi Biotec's R&D department in 2005, she has led the Hematopoietic Stem Cell group, focusing on developing automated processes for manufacturing gene-engineered HSCs.
Katharina Krämer
Katharina Krämer
Global Product Manager at Miltenyi Biotec

Katharina is the Global Product Manager for the CliniMACS CD34 Product Line at Miltenyi Biotec, earned her master's degree in Medical Biology from Radboud University Nijmegen in 2011. She has extensive experience in personalized healthcare and joined Miltenyi Biotec in 2016 to manage the CliniMACS CD34 Product Line.