Vector bioprocessing

CELL AND GENE THERAPY INSIGHTS

April 2022

Vector bioprocessing

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Foreword

Vector bioprocessing spotlight

Vector bioprocessing spotlight

Research Article

Clarification of recombinant adeno-associated virus (rAAV) & lentivirus from adherent culture

Clarification of recombinant adeno-associated virus (rAAV) & lentivirus from adherent culture

Rajeshwar Chinnawar, Nicholas Marchand

Expert Insight

Adeno-associated virus process development: optimization & development of a scalable elution for polishing chromatography

Adeno-associated virus process development: optimization & development of a scalable elution for polishing chromatography

Adeno-associated viral vector process development challenges in early research & preclinical study

Adeno-associated viral vector process development challenges in early research & preclinical study

Innovator Insight

From cells to purified capsids: How to develop a scalable rAAV process

From cells to purified capsids: How to develop a scalable rAAV process

Åsa Hagner McWhirter

Process development innovations to improve gene therapy manufacturing

Process development innovations to improve gene therapy manufacturing

Jessica Hilmoe, Michael Shen

Accelerating cell & gene therapy workflows with next-generation analytical tools

Accelerating cell & gene therapy workflows with next-generation analytical tools

Flexible & scalable solutions for AAV viral vector production using a templated platform

Flexible & scalable solutions for AAV viral vector production using a templated platform

Expert Roundtable Video

Thinking big: the need for innovation in the production of lentivirus-based cell and gene therapies

Thinking big: the need for innovation in the production of lentivirus-based cell and gene therapies

H Leinonen, J Moscariello, L Davies et al.

FastFacts

POROS CaptureSelect AAVX Wash Optimization Study for Optimized Recovery and Purity of AAV6 Capsids

POROS CaptureSelect AAVX Wash Optimization Study for Optimized Recovery and Purity of AAV6 Capsids

Detecting residual host cell DNA with Droplet Digital PCR technology

Detecting residual host cell DNA with Droplet Digital PCR technology

Poster

Manufacturing of RCA-free adenoviral vectors

Manufacturing of RCA-free adenoviral vectors

Viewpoint

Future trends in viral vector process & product development

Future trends in viral vector process & product development

Considerations for demonstrating comparability of AAV processes

Considerations for demonstrating comparability of AAV processes

Interview

Exploring commercial upstream processing of AAV

Exploring commercial upstream processing of AAV

Webinars

Flexible and scalable solutions for AAV viral vector production using a templated platform

Flexible and scalable solutions for AAV viral vector production using a templated platform

What does Plug-and-Play offer large-scale AAV manufacturing?

What does Plug-and-Play offer large-scale AAV manufacturing?

Margherita Neri, Claire Wartel-Weill

A scalable lentiviral vector production system based on stable producer cell lines

A scalable lentiviral vector production system based on stable producer cell lines

Roy Bin Liu

Discovery to manufacturing: A continuum

Discovery to manufacturing: A continuum

A Chang, T Hitchcock, B Fry

Increasing productivity of IVT reaction using at-line monitoring by HPLC chromatography

Increasing productivity of IVT reaction using at-line monitoring by HPLC chromatography

Rok Sekirnik

Process development innovations to improve gene therapy manufacturing

Process development innovations to improve gene therapy manufacturing

Jessica Hilmoe, Michael Shen

Removing technological barriers to efficient large-scale LV vector production

Removing technological barriers to efficient large-scale LV vector production

R Lopez de Maturana, E Jackson-Holmes, M Neri et al.

From cells to purified capsids: How to develop a scalable rAAV process

From cells to purified capsids: How to develop a scalable rAAV process

Åsa Hagner McWhirter

Manufacturing considerations for viral and non-viral platform selection

Manufacturing considerations for viral and non-viral platform selection

V Slepushkin , A Noyes, A Hagerman et al.

Applying an HPLC analytical platform for mRNA process monitoring

Applying an HPLC analytical platform for mRNA process monitoring

Nejc Pavlin