Critical quality attributes for AAV analysis

In this webinar, we will hear from Phenomenex’s Senior Research Scientist, Shilin Cheung as we delve into chromatography’s vital role in ensuring quality and safety of Adeno-Associated Viruses (AAVs) in drug development. We’ll explore the latest modern chromatographic techniques designed to support AAV quantification and characterization.

Critical quality attributes (CQAs) play a pivotal role in every stage of the drug development process. This session will guide you through the nuances of CQAs, providing a comprehensive understanding of their significance and impact. You'll gain valuable insights into how to navigate common challenges posed by CQAs at various development stages, ensuring that your AAV-based therapies meet the highest industry standards.

As we progress, we'll discuss the importance of selecting fit-for-purpose chemistries and method conditions, specifically tailored to address common CQA tests. These insights are instrumental in ensuring that your analytical methods are robust, efficient, and precise.

• Modern chromatographic approaches for comprehensive quantification and characterization of AAVs
• CQA considerations during different drug development stages
• Fit-for-purpose chemistries and review of method conditions to address common AAV CQA tests

Shilin Cheung

Senior Research Scientist at Phenomenex

Dr Cheung received her BS (2006) and PhD (2012) in Bioanalytical Chemistry from the University of Toronto. She has developed, qualified, and validated innovative analytical methods in CE based microfluidics, automated low volume UV-vis spec., and UHPLC assays. Her methods have been applied to manufacturing process developments, formulation and stability and DS/DP characterization and specification testing. At the Phenomenex Innovation Campus she is focused on developing fit for purpose analytical methods to help advance developments in gene therapeutics.

Watch now

SPEAKERS

Shilin Cheung

Senior Research Scientist at Phenomenex

You might also like

Considerations in leveraging the Universal AAV Standard for dPCR to assess AAV genomes quantity and quality

Andrzej Noyszewski, Alex Deiulio

10 September

Watch

Advances in the separation and analysis of AAV-based gene delivery vectors

Jukka Kervinen, Yuliya McAnany

21 November

Watch

Empowering patient care: in-process and quality control solutions for cellular therapies

Christin Tischner, Simon Lennartz

23 May

Watch

Characterization and release testing for AAV therapies: empty/partial/full capsid analysis and impact on potency

K Doucette, F Vass, K Bertram

25 July

Watch