Mastering IP-RPLC-MS for high-throughput & high-resolution oligonucleotide impurity profiling

Sebastiaan Eeltink, Quang-Dong Bui

22 April 2025

Register

A scalable purification strategy for removal of dsRNA byproducts following IVT RNA production

Nathaniel Clark

09 April 2025

Watch

Chemical modifications for therapeutic aptamers

H Rose, A Ansari, E A Hassan et al

07 April 2025

Review

For the many and the few: bringing ASO therapies to both mainstream and nano-rare indications

Stanley Crooke

12 March 2025

Interview

Unveiling the potential of RNA-targeting therapies

Rabia Khan, Loïc Roux

05 December 2024

Review

Tackling the key challenges for therapeutic oligonucleotide manufacture: cost, scale, and sustainability

Ben Andrews

26 November 2024

Interview

Bridging the translational gap: humanized liver models as predictive tools for RNA therapeutic success

Matthew Baginski, Sara Donnelly

21 November 2024

Innovator Insight

mRNA characterization - from 5’ cap to poly (A): what IPRP-LC–MS can tell you

Roxana Eggleston

06 November 2024

Watch

Advancing treatment of genetic diseases through engineered tRNA therapeutics

William Kiesman

24 September 2024

Interview

Delivering on the next generation of oligo therapies depends on overcoming, not ignoring, that sequence and chemistry are separable, but not independent

Chris Hart

08 August 2024

Viewpoint

Harnessing the potential of AI/ML to expand the horizons of the oligonucleotide therapeutics field

Arijit Bhowmick

27 June 2024

Interview

Exploring issues and opportunities in the development of platform technologies for oligonucleotide manufacturing

Jeske Smink

03 June 2024

Interview

Insights into manufacturing lab-scale in vitro transcribed RNA modalities

Andrew Varley

21 May 2024

Expert Insight

The chemistry and biology of oligonucleotide conjugation

Sritama Bose, Peter L Oliver

28 March 2024

Commentary

Pushing the boundaries of siRNA targeting and delivery

Merle Fuchs

20 March 2024

Interview

Glimpsing the future of siRNA delivery strategies and the broader therapeutic application of oligonucleotides

Naim Nazef

12 March 2024

Viewpoint

Comparative analysis of nucleic acid delivery systems for gene therapy: assessing viral and non-viral approaches with emphasis on extracellular vesicles

Nizar Saad

28 February 2024

Commentary

Wall Street analyst’s perspective: taking the pulse of the nucleic acid-based prophylactic & therapeutic vaccine sectors

Hartaj Singh

23 February 2024

Interview

The evolving realm of nucleic acids: past, present, and future

Chris Mason

22 February 2024

Viewpoint

Developing oligonucleotide therapeutics with confidence

Lucy Cook

06 August 2023

FastFacts